Webinar Overview

The bioconjugate landscape is evolving beyond traditional ADCs toward next generation ADCs such as bispecific ADCs and dual payload ADCs. While these modalities expand therapeutic potential, they also introduce more complex CMC requirements in conjugation process development, including tighter control of DAR profiles, intermediate stability, impurity clearance, and process scalability.

In this webinar, Dr. Peng will review the current ADC landscape and share key considerations and platform strategies to accelerate conjugation process development for next-gen ADCs. Using practical examples, the session will cover how to design and optimize site-specific conjugation process, how to develop stepwise, in-process-control (IPC) strategies for dual-payload ADCs, and how to improve impurity control for novel payload linkers.

Key takeaways

· Understand the current ADC landscape and key trends in next-gen ADCs

· Identify the major CMC challenges introduced by next-gen ADC designs

· Explain the development strategies for site specific conjugation processes

· Develop robust conjugation processes for dual-payload ADCs

· Evaluate impurity removal strategy for novel payload linkers

Speaker

Qiang Peng, Ph.D.

Director of ADC Conjugation Process Development, AsymBio